Click here for a photo gallery from the game.
Last week, head coach Beth Dunkenberger and her team found out they would be without star forward Brittany Cook all season due to a torn ACL.
Friday, the Hokies hung on to beat UNC Greensboro 59-53.
Tuesday, they showed once again that with or without Cook, they can still win close and impressively.
The Hokies started the game by going on a 10-0 run that lasted more than five minutes to take an early lead over the Highlanders, 14-4.
The Tech women continued to apply pressure, outrebounding Radford, 19-14, and holding the Highlanders to 25 percent shooting in through the first 20 minutes of play.
The Hokies went into halftime on a four-minute, 7-0 spurt that extended the lead to 34-17.
So far this year, the Hokies have had a hard time maintaining consistent play.
"Unfortunately, we fill our heads with a little Latin exam where we break down defensively and let other teams go on runs," Dunkenberger said.
In the second half, the Hokies did not let up.
With 16:26 left in the game, Radford finally ended a 14-0 Hokie run that had started with over four minutes remaining in the first half.
Four Hokies ended the night in double figures.
Junior forward Utaha Drye, sophomore guard Shani Grey and junior guard Lindsay Biggs outscored everyone on the floor, including everyone on the Radford squad. Junior guard Lakeisha Logan added 10 in the effort, as well.
Shani Grey led the attack with a career-high 17 points on 5-of-8 shooting and six rebounds in just 24 minutes.
"I talked to (Shani) about doing the things that make her special, being a defensive specialist, being a spark that gets hands on balls, gets rebounds," Dunkenberger said.
"When she does those things, the offense seems to come around," she said.
Biggs was active all night long under the basket. She said the team talked prior to the game about stepping up now that they've lost quality players like Cook.
"A few players are hurt, Cook's out -- everyone on the team has to step it up," she said."
The junior scored 15 points on 6-of-11 from the field while recording eight rebounds and dishing out a career-high six assists.
"I just tried to do that. I just tried to look for my shot, create for other people, and my teammates were making it," she said.
Down low, Drye was 6-for-10, pouring in 14 points and adding five boards and five assists in 32 minutes.
The Hokies held their largest lead of the game with 10:59 left when they were up by 33 points to the tune of 58-25 after a lay-up by sophomore forward Brittany Gordon.
Radford didn't stand a chance for the rest of the half, only getting as close as 17 points behind with just three minutes to go.
Junior forward Kymesha Alston led the Highlanders with 11 points, eight rebounds and one assist on the evening. Junior forward Charron Leeper and Radford senior guard Johnette Walker also added 11 points apiece in the game.
Radford fell to 0-2 on the season, while the Hokies kept their record unblemished. Tuesday night's contest was the 29th meeting between the two clubs, with Tech now holding a 20-9 lead in the series.
The Hokies have won 11 of their last 14 against Radford and Dunkenberger is 4-1 in her matches against the New River Valley rival.
Tech will attempt to go for its third straight win to open the new year on Thursday night when it faces-off against North Carolina Central at 7 p.m. at Cassell Coliseum.
On Sunday, the team will travel to Fairfax in a match-up with George Mason before it heads to face off in the Vanderbilt Thanksgiving Tournament in Nashville, Tenn., over the break.
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